Myostatin antibody (LY2495655) in older weak fallers: a proof-of-concept, randomised, phase 2 trial.
Identifieur interne : 002B02 ( Main/Exploration ); précédent : 002B01; suivant : 002B03Myostatin antibody (LY2495655) in older weak fallers: a proof-of-concept, randomised, phase 2 trial.
Auteurs : Clemens Becker [Allemagne] ; Stephen R. Lord [Australie] ; Stephanie A. Studenski [États-Unis] ; Stuart J. Warden [États-Unis] ; Roger A. Fielding [États-Unis] ; Christopher P. Recknor [États-Unis] ; Marc C. Hochberg [États-Unis] ; Serge L. Ferrari [Suisse] ; Hubert Blain [France] ; Ellen F. Binder [États-Unis] ; Yves Rolland [France] ; Serge Poiraudeau [France] ; Charles T. Benson [États-Unis] ; Stephen L. Myers [États-Unis] ; Leijun Hu [États-Unis] ; Qasim I. Ahmad [États-Unis] ; Kelli R. Pacuch [États-Unis] ; Elisa V. Gomez [États-Unis] ; Olivier Benichou [France]Source :
- The lancet. Diabetes & endocrinology [ 2213-8595 ] ; 2015.
Descripteurs français
- KwdFr :
- Anticorps monoclonaux humanisés (administration et posologie), Anticorps monoclonaux humanisés (effets indésirables), Anticorps monoclonaux humanisés (usage thérapeutique), Chutes accidentelles, Démarche (), Faiblesse musculaire (traitement médicamenteux), Femelle, Force de préhension manuelle, Humains, Injections sous-cutanées, Muscles squelettiques (), Myostatine (antagonistes et inhibiteurs), Myostatine (immunologie), Mâle, Méthode en double aveugle, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus.
- MESH :
- administration et posologie : Anticorps monoclonaux humanisés.
- antagonistes et inhibiteurs : Myostatine.
- effets indésirables : Anticorps monoclonaux humanisés.
- immunologie : Myostatine.
- traitement médicamenteux : Faiblesse musculaire.
- usage thérapeutique : Anticorps monoclonaux humanisés.
- Chutes accidentelles, Démarche, Femelle, Force de préhension manuelle, Humains, Injections sous-cutanées, Muscles squelettiques, Mâle, Méthode en double aveugle, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus.
English descriptors
- KwdEn :
- Accidental Falls, Aged, Aged, 80 and over, Antibodies, Monoclonal, Humanized (administration & dosage), Antibodies, Monoclonal, Humanized (adverse effects), Antibodies, Monoclonal, Humanized (therapeutic use), Double-Blind Method, Female, Gait (drug effects), Hand Strength, Humans, Injections, Subcutaneous, Male, Muscle Weakness (drug therapy), Muscle, Skeletal (drug effects), Myostatin (antagonists & inhibitors), Myostatin (immunology), Treatment Outcome.
- MESH :
- chemical , administration & dosage : Antibodies, Monoclonal, Humanized.
- chemical , adverse effects : Antibodies, Monoclonal, Humanized.
- chemical , antagonists & inhibitors : Myostatin.
- chemical , immunology : Myostatin.
- chemical , therapeutic use : Antibodies, Monoclonal, Humanized.
- drug effects : Gait, Muscle, Skeletal.
- drug therapy : Muscle Weakness.
- Accidental Falls, Aged, Aged, 80 and over, Double-Blind Method, Female, Hand Strength, Humans, Injections, Subcutaneous, Male, Treatment Outcome.
Abstract
Myostatin inhibits skeletal muscle growth. The humanised monoclonal antibody LY2495655 (LY) binds and neutralises myostatin. We aimed to test whether LY increases appendicular lean body mass (aLBM) and improves physical performance in older individuals who have had recent falls and low muscle strength and power.
DOI: 10.1016/S2213-8587(15)00298-3
PubMed: 26516121
Affiliations:
- Allemagne, Australie, France, Suisse, États-Unis
- Bade-Wurtemberg, District de Stuttgart, Géorgie (États-Unis), Indiana, Languedoc-Roussillon, Maryland, Massachusetts, Midi-Pyrénées, Missouri (État), Occitanie (région administrative), Pennsylvanie, Île-de-France
- Montpellier, Paris, Pittsburgh, Saint-Louis (Missouri), Stuttgart, Toulouse
- Université de Pittsburgh, École de médecine (Université Washington de Saint-Louis)
Links toward previous steps (curation, corpus...)
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- to stream PubMed, to step Checkpoint: 002591
- to stream Ncbi, to step Merge: 002C91
- to stream Ncbi, to step Curation: 002C91
- to stream Ncbi, to step Checkpoint: 002C91
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- to stream Main, to step Curation: 002B02
Le document en format XML
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Ahmad</name><affiliation wicri:level="2"><nlm:affiliation>Eli Lilly and Company, Indianapolis, IN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Eli Lilly and Company, Indianapolis, IN</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Pacuch, Kelli R" sort="Pacuch, Kelli R" uniqKey="Pacuch K" first="Kelli R" last="Pacuch">Kelli R. Pacuch</name><affiliation wicri:level="2"><nlm:affiliation>Eli Lilly and Company, Indianapolis, IN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Eli Lilly and Company, Indianapolis, IN</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Gomez, Elisa V" sort="Gomez, Elisa V" uniqKey="Gomez E" first="Elisa V" last="Gomez">Elisa V. Gomez</name><affiliation wicri:level="2"><nlm:affiliation>Eli Lilly and Company, Indianapolis, IN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Eli Lilly and Company, Indianapolis, IN</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Benichou, Olivier" sort="Benichou, Olivier" uniqKey="Benichou O" first="Olivier" last="Benichou">Olivier Benichou</name><affiliation wicri:level="1"><nlm:affiliation>Eli Lilly and Company, Neuilly, France. Electronic address: benichou_olivier@lilly.com.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Eli Lilly and Company, Neuilly</wicri:regionArea><wicri:noRegion>Neuilly</wicri:noRegion><wicri:noRegion>Neuilly</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26516121</idno><idno type="pmid">26516121</idno><idno type="doi">10.1016/S2213-8587(15)00298-3</idno><idno type="wicri:Area/PubMed/Corpus">002660</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002660</idno><idno type="wicri:Area/PubMed/Curation">002591</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002591</idno><idno type="wicri:Area/PubMed/Checkpoint">002591</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002591</idno><idno type="wicri:Area/Ncbi/Merge">002C91</idno><idno type="wicri:Area/Ncbi/Curation">002C91</idno><idno type="wicri:Area/Ncbi/Checkpoint">002C91</idno><idno type="wicri:Area/Main/Merge">002B02</idno><idno type="wicri:Area/Main/Curation">002B02</idno><idno type="wicri:Area/Main/Exploration">002B02</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Myostatin antibody (LY2495655) in older weak fallers: a proof-of-concept, randomised, phase 2 trial.</title><author><name sortKey="Becker, Clemens" sort="Becker, Clemens" uniqKey="Becker C" first="Clemens" last="Becker">Clemens Becker</name><affiliation wicri:level="3"><nlm:affiliation>Robert-Bosch-Krankenhaus, Stuttgart, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Robert-Bosch-Krankenhaus, Stuttgart</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Stuttgart</region><settlement type="city">Stuttgart</settlement></placeName></affiliation></author><author><name sortKey="Lord, Stephen R" sort="Lord, Stephen R" uniqKey="Lord S" first="Stephen R" last="Lord">Stephen R. Lord</name><affiliation wicri:level="1"><nlm:affiliation>NeuRA, UNSW, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>NeuRA, UNSW, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Studenski, Stephanie A" sort="Studenski, Stephanie A" uniqKey="Studenski S" first="Stephanie A" last="Studenski">Stephanie A. Studenski</name><affiliation wicri:level="4"><nlm:affiliation>University of Pittsburgh, Pittsburgh, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Warden, Stuart J" sort="Warden, Stuart J" uniqKey="Warden S" first="Stuart J" last="Warden">Stuart J. Warden</name><affiliation wicri:level="2"><nlm:affiliation>School of Health and Rehabilitation Sciences, Indiana University, Indianapolis, IN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Health and Rehabilitation Sciences, Indiana University, Indianapolis, IN</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Fielding, Roger A" sort="Fielding, Roger A" uniqKey="Fielding R" first="Roger A" last="Fielding">Roger A. Fielding</name><affiliation wicri:level="2"><nlm:affiliation>Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Recknor, Christopher P" sort="Recknor, Christopher P" uniqKey="Recknor C" first="Christopher P" last="Recknor">Christopher P. Recknor</name><affiliation wicri:level="2"><nlm:affiliation>United Osteoporosis Centers, Gainesville, GA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>United Osteoporosis Centers, Gainesville, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Hochberg, Marc C" sort="Hochberg, Marc C" uniqKey="Hochberg M" first="Marc C" last="Hochberg">Marc C. Hochberg</name><affiliation wicri:level="2"><nlm:affiliation>University of Maryland School of Medicine, Baltimore, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Maryland School of Medicine, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Ferrari, Serge L" sort="Ferrari, Serge L" uniqKey="Ferrari S" first="Serge L" last="Ferrari">Serge L. Ferrari</name><affiliation wicri:level="1"><nlm:affiliation>Geneva University Hospital, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Geneva University Hospital, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Blain, Hubert" sort="Blain, Hubert" uniqKey="Blain H" first="Hubert" last="Blain">Hubert Blain</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine and Geriatrics, Montpellier University Hospital, M2H, MACVIA-LR, Montpellier University, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Internal Medicine and Geriatrics, Montpellier University Hospital, M2H, MACVIA-LR, Montpellier University, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Binder, Ellen F" sort="Binder, Ellen F" uniqKey="Binder E" first="Ellen F" last="Binder">Ellen F. Binder</name><affiliation wicri:level="4"><nlm:affiliation>Washington University School of Medicine, St Louis, MO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Washington University School of Medicine, St Louis, MO</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Rolland, Yves" sort="Rolland, Yves" uniqKey="Rolland Y" first="Yves" last="Rolland">Yves Rolland</name><affiliation wicri:level="3"><nlm:affiliation>Gérontopôle de Toulouse, Centre Hospitalo‑Universitaire de Toulouse, and INSERM 1027, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gérontopôle de Toulouse, Centre Hospitalo‑Universitaire de Toulouse, and INSERM 1027, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Poiraudeau, Serge" sort="Poiraudeau, Serge" uniqKey="Poiraudeau S" first="Serge" last="Poiraudeau">Serge Poiraudeau</name><affiliation wicri:level="3"><nlm:affiliation>Department of Physical Rehabilitation for Musculoskeletal and Spinal Disorders, Cochin Hospital, Paris, France; Paris Descartes University, Paris, France; INSERM U1153, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Physical Rehabilitation for Musculoskeletal and Spinal Disorders, Cochin Hospital, Paris, France; Paris Descartes University, Paris, France; INSERM U1153, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Benson, Charles T" sort="Benson, Charles T" uniqKey="Benson C" first="Charles T" last="Benson">Charles T. Benson</name><affiliation wicri:level="2"><nlm:affiliation>Eli Lilly and Company, Indianapolis, IN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Eli Lilly and Company, Indianapolis, IN</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Myers, Stephen L" sort="Myers, Stephen L" uniqKey="Myers S" first="Stephen L" last="Myers">Stephen L. Myers</name><affiliation wicri:level="2"><nlm:affiliation>Eli Lilly and Company, Indianapolis, IN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Eli Lilly and Company, Indianapolis, IN</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Hu, Leijun" sort="Hu, Leijun" uniqKey="Hu L" first="Leijun" last="Hu">Leijun Hu</name><affiliation wicri:level="2"><nlm:affiliation>Eli Lilly and Company, Indianapolis, IN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Eli Lilly and Company, Indianapolis, IN</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Ahmad, Qasim I" sort="Ahmad, Qasim I" uniqKey="Ahmad Q" first="Qasim I" last="Ahmad">Qasim I. Ahmad</name><affiliation wicri:level="2"><nlm:affiliation>Eli Lilly and Company, Indianapolis, IN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Eli Lilly and Company, Indianapolis, IN</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Pacuch, Kelli R" sort="Pacuch, Kelli R" uniqKey="Pacuch K" first="Kelli R" last="Pacuch">Kelli R. Pacuch</name><affiliation wicri:level="2"><nlm:affiliation>Eli Lilly and Company, Indianapolis, IN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Eli Lilly and Company, Indianapolis, IN</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Gomez, Elisa V" sort="Gomez, Elisa V" uniqKey="Gomez E" first="Elisa V" last="Gomez">Elisa V. Gomez</name><affiliation wicri:level="2"><nlm:affiliation>Eli Lilly and Company, Indianapolis, IN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Eli Lilly and Company, Indianapolis, IN</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Benichou, Olivier" sort="Benichou, Olivier" uniqKey="Benichou O" first="Olivier" last="Benichou">Olivier Benichou</name><affiliation wicri:level="1"><nlm:affiliation>Eli Lilly and Company, Neuilly, France. Electronic address: benichou_olivier@lilly.com.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Eli Lilly and Company, Neuilly</wicri:regionArea><wicri:noRegion>Neuilly</wicri:noRegion><wicri:noRegion>Neuilly</wicri:noRegion></affiliation></author></analytic><series><title level="j">The lancet. Diabetes & endocrinology</title><idno type="eISSN">2213-8595</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Accidental Falls</term><term>Aged</term><term>Aged, 80 and over</term><term>Antibodies, Monoclonal, Humanized (administration & dosage)</term><term>Antibodies, Monoclonal, Humanized (adverse effects)</term><term>Antibodies, Monoclonal, Humanized (therapeutic use)</term><term>Double-Blind Method</term><term>Female</term><term>Gait (drug effects)</term><term>Hand Strength</term><term>Humans</term><term>Injections, Subcutaneous</term><term>Male</term><term>Muscle Weakness (drug therapy)</term><term>Muscle, Skeletal (drug effects)</term><term>Myostatin (antagonists & inhibitors)</term><term>Myostatin (immunology)</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Anticorps monoclonaux humanisés (administration et posologie)</term><term>Anticorps monoclonaux humanisés (effets indésirables)</term><term>Anticorps monoclonaux humanisés (usage thérapeutique)</term><term>Chutes accidentelles</term><term>Démarche ()</term><term>Faiblesse musculaire (traitement médicamenteux)</term><term>Femelle</term><term>Force de préhension manuelle</term><term>Humains</term><term>Injections sous-cutanées</term><term>Muscles squelettiques ()</term><term>Myostatine (antagonistes et inhibiteurs)</term><term>Myostatine (immunologie)</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antibodies, Monoclonal, Humanized</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antibodies, Monoclonal, Humanized</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Myostatin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Myostatin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antibodies, Monoclonal, Humanized</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Anticorps monoclonaux humanisés</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Myostatine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Gait</term><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Muscle Weakness</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Anticorps monoclonaux humanisés</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Myostatine</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Faiblesse musculaire</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anticorps monoclonaux humanisés</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Accidental Falls</term><term>Aged</term><term>Aged, 80 and over</term><term>Double-Blind Method</term><term>Female</term><term>Hand Strength</term><term>Humans</term><term>Injections, Subcutaneous</term><term>Male</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Chutes accidentelles</term><term>Démarche</term><term>Femelle</term><term>Force de préhension manuelle</term><term>Humains</term><term>Injections sous-cutanées</term><term>Muscles squelettiques</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Myostatin inhibits skeletal muscle growth. The humanised monoclonal antibody LY2495655 (LY) binds and neutralises myostatin. We aimed to test whether LY increases appendicular lean body mass (aLBM) and improves physical performance in older individuals who have had recent falls and low muscle strength and power.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>France</li><li>Suisse</li><li>États-Unis</li></country><region><li>Bade-Wurtemberg</li><li>District de Stuttgart</li><li>Géorgie (États-Unis)</li><li>Indiana</li><li>Languedoc-Roussillon</li><li>Maryland</li><li>Massachusetts</li><li>Midi-Pyrénées</li><li>Missouri (État)</li><li>Occitanie (région administrative)</li><li>Pennsylvanie</li><li>Île-de-France</li></region><settlement><li>Montpellier</li><li>Paris</li><li>Pittsburgh</li><li>Saint-Louis (Missouri)</li><li>Stuttgart</li><li>Toulouse</li></settlement><orgName><li>Université de Pittsburgh</li><li>École de médecine (Université Washington de Saint-Louis)</li></orgName></list><tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Becker, Clemens" sort="Becker, Clemens" uniqKey="Becker C" first="Clemens" last="Becker">Clemens Becker</name></region></country><country name="Australie"><noRegion><name sortKey="Lord, Stephen R" sort="Lord, Stephen R" uniqKey="Lord S" first="Stephen R" last="Lord">Stephen R. Lord</name></noRegion></country><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Studenski, Stephanie A" sort="Studenski, Stephanie A" uniqKey="Studenski S" first="Stephanie A" last="Studenski">Stephanie A. Studenski</name></region><name sortKey="Ahmad, Qasim I" sort="Ahmad, Qasim I" uniqKey="Ahmad Q" first="Qasim I" last="Ahmad">Qasim I. Ahmad</name><name sortKey="Benson, Charles T" sort="Benson, Charles T" uniqKey="Benson C" first="Charles T" last="Benson">Charles T. Benson</name><name sortKey="Binder, Ellen F" sort="Binder, Ellen F" uniqKey="Binder E" first="Ellen F" last="Binder">Ellen F. Binder</name><name sortKey="Fielding, Roger A" sort="Fielding, Roger A" uniqKey="Fielding R" first="Roger A" last="Fielding">Roger A. Fielding</name><name sortKey="Gomez, Elisa V" sort="Gomez, Elisa V" uniqKey="Gomez E" first="Elisa V" last="Gomez">Elisa V. Gomez</name><name sortKey="Hochberg, Marc C" sort="Hochberg, Marc C" uniqKey="Hochberg M" first="Marc C" last="Hochberg">Marc C. Hochberg</name><name sortKey="Hu, Leijun" sort="Hu, Leijun" uniqKey="Hu L" first="Leijun" last="Hu">Leijun Hu</name><name sortKey="Myers, Stephen L" sort="Myers, Stephen L" uniqKey="Myers S" first="Stephen L" last="Myers">Stephen L. Myers</name><name sortKey="Pacuch, Kelli R" sort="Pacuch, Kelli R" uniqKey="Pacuch K" first="Kelli R" last="Pacuch">Kelli R. Pacuch</name><name sortKey="Recknor, Christopher P" sort="Recknor, Christopher P" uniqKey="Recknor C" first="Christopher P" last="Recknor">Christopher P. Recknor</name><name sortKey="Warden, Stuart J" sort="Warden, Stuart J" uniqKey="Warden S" first="Stuart J" last="Warden">Stuart J. Warden</name></country><country name="Suisse"><noRegion><name sortKey="Ferrari, Serge L" sort="Ferrari, Serge L" uniqKey="Ferrari S" first="Serge L" last="Ferrari">Serge L. Ferrari</name></noRegion></country><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Blain, Hubert" sort="Blain, Hubert" uniqKey="Blain H" first="Hubert" last="Blain">Hubert Blain</name></region><name sortKey="Benichou, Olivier" sort="Benichou, Olivier" uniqKey="Benichou O" first="Olivier" last="Benichou">Olivier Benichou</name><name sortKey="Poiraudeau, Serge" sort="Poiraudeau, Serge" uniqKey="Poiraudeau S" first="Serge" last="Poiraudeau">Serge Poiraudeau</name><name sortKey="Rolland, Yves" sort="Rolland, Yves" uniqKey="Rolland Y" first="Yves" last="Rolland">Yves Rolland</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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